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Coding for >700 (but <800) Amino Acids. - Gtx0 ?>


Coding for >700 (but <800) Amino Acids.
Posted: Posted January 15th by chiarizio
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There are more than 700 amino acids in nature.
There are fewer than 800;
And most of them are not naturally “proteinogenic”.

There can theoretically be any even number between 2 and 12 different chemical species of nucleobase.
Codons can be quite long.

With 2 or more kinds of nucleobase, and 10 or more nucleobases per codon, we could have >= 2^10 = 1024 codon-types.
With 4 or more kinds of nucleobase, and 5 or more nucleobases per codon, we could have >= 4^5 = 1024 codon-types.
With 6 or more kinds of nucleobase, and 4 or more nucleobases per codon, we could have >= 6^4 = 1296 codon-types.
With 10 or more kinds of nucleobase, and 3 or more nucleobases per codon, we could have >= 10^3 = 1000 codon-types.

All of these are bigger than 799.


There are 3 Replies

There can’t be more than 12 different kinds of nucleobase without a significant rewrite of the WatsonCrick type of DNAage.
Assume each one is a pyrimidine (or isomeric to a pyrimidine) or is a purine (or isomeric to a purine).

With 12 different nucleobases and 2 nucleobases per codon, we could have as many as 144 different codes. That’s significantly more than the 64 we have IRL now, but it’s less than 700.

With 8 nucleobases and 3 bases per codon we’d have only 512 different codes.

With 4 nucleobases and 4 bases per codon we’d have only 256.

And with 2 and 9, only 512.


Posted January 22nd by chiarizio
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Experiments have been accomplished that:
  • had ribosomes and tRNAs and mRNAs that could translate codons made out of 6 kinds of nucleobases,
    and
  • had ribosomes and tRNAs and mRNAs that could translate codons that were four bases long,
    and
  • had ribosomes and tRNAs and mRNAs that could translate codons that were five bases long.


  • Posted February 11th by chiarizio
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    Reply to: Coding for >700 (but <800) Amino Acids.
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